Exploratory Behavior and Recognition Memory in Medial Septal Electrolytic, Neuro- and Immunotoxic Lesioned Rats
نویسندگان
چکیده
منابع مشابه
Exploratory behavior and recognition memory in medial septal electrolytic, neuro- and immunotoxic lesioned rats.
In the present study, the effect of the medial septal (MS) lesions on exploratory activity in the open field and the spatial and object recognition memory has been investigated. This experiment compares three types of MS lesions: electrolytic lesions that destroy cells and fibers of passage, neurotoxic - ibotenic acid lesions that spare fibers of passage but predominantly affect the septal nonc...
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Behavioral effects of septal lesions are altered by presurgical history of the experimental animal. We examined the interactions between presurgical handling of young adult rats and subsequent septal lesions on postsurgical exploratory behavior in an open field . Sixty·day·old male rats were either handled twice daily for 20 days prior to surgery or left undisturbed during this period. All rats...
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The Cholinergic and GABAergic .bers of the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neuron...
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Rats were trained to turn for water reinforcement and then were given unilateral 6-hydroxydopamine lesions. After lesion, rats showed deficits in trained turning both contra- and ipsilateral to the side of the lesion, with contralateral turning more severely impaired. The lesioned rats were then transplanted with fetal mesencephalic dopamine tissue into striatum. A control group of lesioned rat...
متن کاملLesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments.
The functional contribution of nucleus basalis magnocellularis (NBM) and the medial septal area (MSA) to memory was evaluated in two different spatial discriminations. Preoperatively, rats were trained to a criterion level of performance in a simultaneous left/right discrimination on the stem of a T-maze (a trial-independent memory) and a discrete-trial, rewarded alternation discrimination on t...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2015
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932809